Abstract :A 10-year-old male with DiGeorge syndrome was referred to Kuwait University Dental Center with a chief complaint of generalized extensive carious lesions. Upon examination, the patient had poor oral hygiene, severe chronic generalized gingivitis, and gross carious lesions on all permanent teeth with the exception of the lower left first premolar. The caries also included the lower permanent central incisors. The medical history identified that the patient was previously treated for surgical correction of Tetralogy of Fallot. The purpose of this case report was to discuss the oral and maxillofacial findings observed in a patient with DiGeorge syndrome.